一、基本情況
趙忠熙，藥劑學專業博士生導師。近五年，先後主持國家“973”計劃和艾滋病和病毒性肝炎等重大傳染病防治國家科技重大專項課題各1項、省部級課題共4項；獲國家發明專利授權4項；發表SCI收錄學術論文35篇。
二、主要研究方向
1.新藥創制：用于治療呼吸系統疾病和腫瘤的小分子免疫治療藥物的研發。
2.中藥大品種再開發：用于治療肺結核、肺癌、糖尿病腎病、慢阻肺等中藥免疫治療藥物的再開發。
3.藥劑學研究：吸入、緩控釋、靶向納米、膜制劑等新型給藥系統關鍵技術和相關産品的研究；高端制劑仿制藥一緻性評價研究。
4.創新醫療器械:用于呼吸系統疾病防治的呼吸治療儀及配套産品開發。
三、承擔重大課題
1. 1.1類抗胃癌新藥“CPD0012”和抗肺癌複方新藥“CPD0004/200”臨床前研究：橫向項目（經費620萬元，在研）；
2.治療耐藥肺結核中藥複方益肺通絡方物質基礎、免疫作用機制研究及相關中藥大品種再開發：國家科技重大專項課題（經費102萬元，2013-2017年）、抗肺癌中藥大品種再開發（在研）；
3.治療耐藥肺結核和肺癌創新醫療器械及配套産品産學研開發：山東省急需緊缺人才項目（經費75萬元，2016-2017年）、橫向項目（經費500萬元，在研）；
4.紅棗和大蒜物質基礎和作用機制研究以及相關保健品和特醫食品産學研開發：國家“973”計劃課題（經費60萬元，2012-2014年）、山東省農業成果轉化項目（經費100萬元，2014-2017年）、山東省急需緊缺人才項目（經費20萬元，2015-2016年）、橫向項目（經費1100萬元，在研）。
四、代表性學術論文（10篇代表性成果）
1. Y. Liu, A. Li, X. Feng, X. Jiang, X. Sun, W. Huang, X. Zhu, Z. Zhao,L-menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa b, p38 MAPK and Nrf2 signalling pathways, RSC Adv., 2018, 8,9353.
2. X. Jiang, X. Zhu, N. Liu, H. Xu, Z. Zhao, S. Li, S. Li, J. Cai and J. Cao, Diallyltrisulfide inhibits growth of NCI-H460 in vitro and in vivo, and ameliorates cisplatin-induced oxidative injury in the treatment of lung Carcinoma,Int. J. Biol. Sci., 2017, 13, 167-178.
3. X. Jiang, X. Zhu, W. Huang, H. Xu, Z. Zhao, S. Li, S. Li, J. Cai, J. Cao, Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice, Int. Immunopharm., 2017, 48, 135–145.
4. X. Zhu, X. Jiang, A. Li, Z. Zhao and S. Li, S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation, Nutrients, 2017, 9, 166.
5. X. Zhu, X. Jiang, C. Duan, A. Li, Y. Sun, Q. Qi, Y. Liu, S. Li and Z. Zhao, S-Allylmercaptocysteine induces G2/M phase arrest and apoptosis via ROS-mediated p38 and JNK signaling pathway in human colon cancer cells in vitro and in vivo, RSC Adv., 2017, 7, 49151.
6. X. Zhu, X. Jiang, A. Li, Y. Sun, Y. Liu, X. Sun, X. Feng, S. Li, and Z. Zhao, S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways,Biochem. Biophys. Res. Commun., 2017, 492, 1-6.
7. M. Yang, Z. Dong, Y. Zhang, F. Zhang, Y. Wang and Z. Zhao, Preparation and evaluation of posaconazole-loaded enteric microparticles in rats, Drug Dev. Ind. Pharm., 2017, 43, 618–627.
8. Y. Wang, W. Huang, J. Zhang, M. Yang, Q. Qi, K. Wang, Z. Zhao,The therapeutic effect of Bletilla striata extracts on LPS-induced acute lung injury by the regulations of inflammation and oxidation, RSC Adv., 2016, 6, 89338.
9. Y. Wang, Q. Qi, A. Li, M. Yang, W. Huang, H. Xu, Z. Zhao, and S. Li, Immuno-enhancement effects of YifeiTongluo Granules on cyclophosphamide-induced immunosuppression in Balbc mice, J. Ethnopharmacol., 2016, 194, 72–82.
10. Y. Wang, X. Liu, G. Liu, H. Guo, C. Li, Y. Zhang, F. Zhang, Z. Zhao, H. Cheng, Novel galactosylated biodegradable nanoparticles for hepatocyte-delivery of oridonin, Int. J. Pharm. 2016, 502, 47–60.
