基本信息
單剛，男，博士，推荐几个网赌网站教授，藥物化學專業博士生導師。2019年入選山東大學齊魯青年學者項目和山東省泰山學者青年專家項目。
郵箱: gangshan@sdu.edu.cn
通訊地址：山東省濟南市文化西路44号推荐几个网赌网站
教育背景
2019.06–至今 推荐几个网赌网站，藥物化學專業，教授、博士生導師
2018.04–2019.04 哈佛大學醫學院丹娜法伯癌症研究所，博士後
2015.09–2018.04 德國馬普分子生理學研究所，博士後
2010.09–2015.07 清華大學藥學院，博士
2006.09–2010.07 推荐几个网赌网站，學士
研究方向
1.基于化學反應的診斷治療藥物開發：針對腫瘤微環境的特點，設計腫瘤特異 性的反應，開發近紅外一區和二區的診斷治療藥物，用于腫瘤的治療與活體成像。
2.新型生物兼容反應的開發及其在生物大分子标記和藥物激活中的應用。
3.新型有機合成新方法的開發及其在藥物研發中的應用。
承擔項目
1.山東大學齊魯青年學者項目
2.山東省泰山學者青年專家項目
3.國家自然科學基金青年基金項目
發表論文
1.G. Shan, J. Flegel, H. Li, C. Merten, S. Ziegler, A. P. Antonchick, H. Waldmann.* "C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Novel Hedgehog Pathway Inhibitors "Angew. Chem. Int. Ed.2018, 57, 14250-14254.
2. Z. Jia,G. Shan, C. G. Daniliuc, A. P. Antonchick, H. Waldmann.* "Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis"Angew. Chem. Int. Ed.2018,57, 14493-14497.
3.X.L. Yang+,G. Shan+, Z. Yang, G. Huang, C. Sheng, Y. Rao.* "One-pot Synthesis of Quaternary Carbon Centered Cyclobutanes via Pd(II)-catalyzed Cascade C(sp3)-H Activations"Chem. Comm.2017,53, 1534-1537.
4. X.L. Yang+,G. Shan+, L. Wang, Y. Rao.* "Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups"Tetrahedron Lett. 2016, 56, 819-836.
5.G. Shan, G. Huang, Y. Rao,*H. Zhang.*"Palladium-catalyzedortho-selective C-H bond chlorination of aromatic ketones"Chin. Chem. Lett.2015,26, 1236-1240.
6.G. Shan, G. Huang, Y. Rao.* "Palladium-Catalyzed Unactivated β-Methylene C(sp3)-HBond Alkenylation of Aliphatic Amides and Application in A Sequential C(sp3)-H/C(sp2)-HBond Alkenylation"Org. Biomol. Chem.2015,13, 697-701.
7. Y. Rao*,G. Shan, X. Yang. "Some Recent Advances in Transition-metal-catalyzedorthoSP2C–H Functionalization Using Ru, Rh, and Pd"Science China Chemistry,2014,57, 930-944.
8. X. Yang+,G. Shan+, Y. Rao.* "Synthesis of 2-Aminophenols and Heterocycles by RuCatalyzed Mono- and Double C-H Hydroxylation"Org. Lett.2013,15, 2334-2337.
9.G. Shan, X. Han, Y. Lin, S. Yu, Yu Rao.* "Broadening the Catalyst and Reaction Scopeof Regio- and Chemoselective C-H Oxygenation: A Convenient and Scalable Approach to2-Acylphenols by Intriguing Rh(II) and Ru(II) Catalysis "Org. Biomol. Chem.2013,11,2318-2322.
10.G. Shan+, X. Yang+, Y. Zong, Y. Rao.* "An Efficient Palladium Catalyzed C-HAlkoxylation of Unactivated Methylene and Methyl Groups with Cyclic Hypervalent Iodine(I3+) Oxidants"Angew. Chem. Int. Ed.2013,52, 13606-13610.
11. X. Sun+,G. Shan+, Y. Sun, Y. Rao.* "A General Approach for Regio- and ChemoselectiveC-H Chlorination/Bromination of Electron-Deficient Arenes via Weak Coordination and APreliminary Study of Priority Order of Relative Directing Group Ability"Angew. Chem. Int.Ed.2013,52, 4440-4444.
12.G. Shan, X. Yang, L. Ma, Y. Rao.* "Pd-Catalyzed C-H Oxygenation with TFA/TFAA:Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification"Angew. Chem. Int. Ed.2012,51, 13070-13074.
13.G. Shan, X. Sun, Q. Xia, Y. Rao.* "A Facile Synthesis of Substituted 2-AlkylquinolinesThrough [3+3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at RoomTemperature"Org. Lett.2011,13, 5770-5773.
14.G. Shan, P. Liu, Y. Rao.* "A New Synthesis ofPyrazoles through LewisAcid-Catalyzed-Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines"Org.Lett.2011,13, 1746-1749.
