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張志嶽 教授

一、基本情況

張志嶽,博士,推荐几个网赌网站教授,藥劑學專業博士生導師。2017年入選“山東大學齊魯青年學者”, 截止目前,已在Angewandte Chemie International Edition(2篇), Advanced Functional Materials(3篇),Advanced Healthcare Materials(2篇),Chemistry of Materials等著名綜合性期刊或藥劑學領域頂級學術期刊發表SCI論文20餘篇。現為中國藥學會高級會員,國家公派出國留學評審專家。

通訊地址:山東省濟南市文化西路44号,推荐几个网赌网站

電話:(86)13864186525

Email: zhiyue.zhang@sdu.edu.cn

二、研究領域

方向1:基于多功能聚合物的合成、修飾制備新型藥物傳遞載體。

方向2:靶向修飾納米粒作為藥物傳遞系統的研究。

方向3:藥物遞送系統用于抗腫瘤免疫聯合治療

三、工作及學習經曆

2018.10 -至今, 推荐几个网赌网站,教授、博士生導師

2016.10-2018.09,比利時根特大學(Ghent University, Belgium),博士後研究員

2012.10-2016.05,比利時根特大學(Ghent University, Belgium),博士

2009.09-2012.06,山東大學,碩士

2005.09-2009.06,山東大學,學士

四、承擔課題

1、國家自然科學基金青年項目

2、國家自然科學基金委員會與歐盟委員會“中歐人才項目”

3、山東省自然科學基金青年項目

4、山東大學“齊魯青年學者”科研啟動基金;

5、中澳健康科學研究中心聯合基金

五、代表性學術論文(限10篇)

1)Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, Xuechun Sun, Xinke Zhang, Xiao Wang, Zepeng Li, Qilu Zhang, Hao Wu, Guan Wang, Jian Zhang, Bruno G De Geest*,Zhiyue Zhang*. An Intelligent Nano-vehicle Armed with Multi-functional Navigation for Precise Delivery of Toll-like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity.Advanced Healthcare Materials2022, DOI: 10.1002/adhm.202102739.

2) Yutong Liu†, Hui Li†, Huajun Zhao, Yanyun Hao, Simon Van Herck, Zejun Xu, Guan Wang, Xiao Wang, Xinke Zhang, Xiaoyan Ge, Xia Li, Ailu Yang, Hongfei Chen, Jing Zou, Wentao Wang, Bruno G De Geest*,Zhiyue Zhang*In Situ Tumor Vaccination with Calcium-linked Degradable Coacervate Nanocomplex Co-delivering Photosensitizer and TLR7/8 agonist to Trigger Effective Anti-tumor Immune Responses.Advanced Healthcare Materials2022, DOI: 10.1002/adhm.202102781.

3) Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Lutz Nuhn, Zifu Zhong, Francis Combes, Niek N. Sanders, Stefan Lienenklaus, Stefaan D. Koker, Sunil A. David, Yadong Wang, Bruno G. De Geest*,Zhiyue Zhang*Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.ACS Biomaterials Science & Engineering2020, 6, 4993–5000

4)Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart N. Lambrecht, Richard Hoogenboom, Lutz Nuhn, Bruno G. De Geest*. A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.Angewandte Chemie International Edition2019, 58, 7866-7872.

5)Zhiyue Zhang, Samarendra Maji, André B. da Fonseca Antunes, Riet De Rycke, Richard Hoogenboom*, Bruno G. De Geest* Salt-driven deposition of thermoresponsive polymer-coated metal nanoparticles on solid substrates.Angewandte Chemie International Edition2016, 2016, 55, 7086-7090.

6)Zhiyue Zhang, Katleen Van Steendam, Samarendra Maji, Lieve Balcaen, Yulia Anoshkina, Qilu Zhang, Glenn Vanluchene, Riet De Rycke, Frank Van Haecke, Dieter Deforce, Richard Hoogenboom*, Bruno G. De Geest* Tailoring cellular uptake of gold nanoparticles via the hydrophillic-to-hydrophobic ratio of their (co)polymer coating.Advanced Functional Materials2015, 25, 3433-3439.

7)Zhiyue Zhang†, Samarendra Maji†, André Bruno da Fonseca Antunes, Riet De Rycke, Qilu Zhang, Richard Hoogenboom*, Bruno G. De Geest* Salt Plays a Pivotal Role in the Temperature-Responsive Aggregation and Layer-by-Layer Assembly of Polymer-Decorated Gold Nanoparticles.Chemistry of Materials2013, 25, 4297-4303.

8)Z. Zhang, B. Schepens, L. Nuhn, X. Saelens, M. Schotsaert, N. Callewaert, R. De Rycke, Q. Zhang, S. Moins, S. Benali, L. Mespouille, R. Hoogenboom, B. G. De Geest* Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.Chemical Communications2016, 52, 3352-3355.

9)Zhiyue Zhang, Nane Vanparijs, Stef Vandewalle, Filip E. Du Prez, Lutz Nuhn*, Bruno G. De Geest* Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers.Polymer Chemistry2016, 7, 7242 – 7248

10) Victor R. de la Rosa,Zhiyue Zhang, Bruno G. De Geest, Richard Hoogenboom* Colorimetric Logic gates based on novel poly(2-alkyl-2-oxazoline) coated gold nanoparticles.Advanced Functional Materials2015, 25, 2511-2519.

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